A system for isolating a first power domain from a second power domain in an integrated circuit includes receiving an input signal from the first power domain and receiving a set of bits from a programmable register. An isolation enable signal indicative of isolating the first power domain from the second power domain is generated, and an intermediate signal based on the isolation enable signal and the input signal is generated. At least one of the input signal, a logic low signal, a logic high signal, and the intermediate signal is output based on the isolation enable signal and the set of bits.