Systems and methods are provided for identifying unsolicited or unwanted electronic communications, such as spam. The disclosed embodiments also encompass systems and methods for selecting content items from a content item database. Consistent with certain embodiments, computer-implemented systems and methods may use a clustering based statistical content matching anti-spam algorithm to identify and filter spam. Such a anti-spam algorithm may be implemented to determine a degree of similarity between an incoming e-mail with a collection of one or more spam e-mails stored in a database. If the degree of similarity exceeds a predetermined threshold, the incoming e-mail may be classified as spam. Further, in accordance with other embodiments, systems and methods may be provided to determine a degree of similarity between a query or search string from a user and content items stored in a database. If the degree of similarity exceeds a predetermined threshold, the content item from the database may be identified as a content item that matches the query or search string provided by the user.