Systems and methods for mobile application traffic optimization are disclosed. In one aspect, embodiments of the present disclosure include a distributed proxy and cache system, including, a local proxy on a mobile device for intercepting a data request made via a mobile device, and a proxy server coupled to the mobile device and a content server to which the data request is directed. In one embodiment, the local proxy can forward the data request to the proxy server for transmission to the content server for a response to the data request. In addition, the proxy server sends the data request to the content server independent of activities on the local proxy and notifies the local proxy when changed or different content on the content server is detected for the data request.