A method to selectively compress an image in a printing process comprises the steps of providing a first representation of an image to be printed on a printer to a printing pipeline, processing the first representation in the printing pipeline to derive a second representation of the image, wherein the second representation comprises physical printing parameters adapted to the image and the printer, and compressing the second representation to obtain a compressed third representation of the image. The third representation of the image is again supplied to the printing pipeline, and is processed in the printing pipeline to derive a fourth representation of the image. The fourth representation of the image is provided to a printhead of the printer for printing. The invention also relates to a corresponding system to selectively compress an image in a printing process, as well as to a computer-readable medium comprising computer-readable instructions to cause a computer coupled to or integrated into a system to selectively compress an image in the printing process to perform a method with the steps described above.