Embodiments of the present application provide a method and apparatus for uplink interference avoidance in case of timing advance group reconfiguration. Wherein, the method includes: reconfiguring a TAG belonging to a secondary serving cell by terminal; and terminating, by the terminal, transmission of a periodic channel sounding reference signal Type-0 SRS in the secondary serving cell, and/or terminating, by the terminal, uplink non-adaptive retransmission in the secondary serving cell, after the terminal completes the reconfiguration of the TAG of the secondary serving cell and if a current TAG is a new one. With the embodiments of the present application, a problem of mutual interference with other terminal resulted from transmission of an uplink signal by the terminal in the secondary serving cell according to a wrong TA value may be avoided.