Invention Grant
- Patent Title: Devices, systems, and methods for microscale isoelectric fractionation
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Application No.: US13747587Application Date: 2013-01-23
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Publication No.: US09409357B1Publication Date: 2016-08-09
- Inventor: Gregory J. Sommer , Anson V. Hatch , Ying-Chih Wang , Anup K. Singh
- Applicant: Sandia Corporation
- Applicant Address: US NM Albuquerque
- Assignee: Sandia Corporation
- Current Assignee: Sandia Corporation
- Current Assignee Address: US NM Albuquerque
- Agency: Medley, Behrens & Lewis, LLC
- Main IPC: B29D7/01
- IPC: B29D7/01

Abstract:
Embodiments of the present invention provide devices, systems, and methods for microscale isoelectric fractionation. Analytes in a sample may be isolated according to their isoelectric point within a fractionation microchannel. A microfluidic device according to an embodiment of the invention includes a substrate at least partially defining a fractionation microchannel. The fractionation microchannel has at least one cross-sectional dimension equal to or less than 1 mm. A plurality of membranes of different pHs are disposed in the microchannel. Analytes having an isoelectric point between the pH of the membranes may be collected in a region of the fractionation channel between the first and second membranes through isoelectric fractionation.
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