Invention Grant
US09409892B2 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors
有权
4-羟基 - 异喹啉化合物作为HIF羟化酶抑制剂
- Patent Title: 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors
- Patent Title (中): 4-羟基 - 异喹啉化合物作为HIF羟化酶抑制剂
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Application No.: US14383874Application Date: 2013-03-08
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Publication No.: US09409892B2Publication Date: 2016-08-09
- Inventor: Wen-Bin Ho , Hongda Zhao , Shaojiang Deng , Danny Ng , Lee R. Wright , Min Wu , Xiaoti Zhou , Michael P. Arend , Lee A. Flippin
- Applicant: FIBROGEN, INC.
- Applicant Address: US CA San Francisco
- Assignee: FibroGen, Inc.
- Current Assignee: FibroGen, Inc.
- Current Assignee Address: US CA San Francisco
- Agency: Sheppard Mullin Richter & Hampton LLP
- Agent Leanne C. Price
- International Application: PCT/US2013/029912 WO 20130308
- International Announcement: WO2013/134660 WO 20130912
- Main IPC: C07D217/26
- IPC: C07D217/26 ; C07D401/12 ; A61K31/44 ; A61K31/47 ; C07D409/12 ; C07D401/04 ; C07D405/12
Abstract:
The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.
Public/Granted literature
- US20150038528A1 4 -HYDROXY- ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS Public/Granted day:2015-02-05
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