Invention Grant
- Patent Title: Modulation of midbody derivatives
- Patent Title (中): 中体衍生物的调制
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Application No.: US14342662Application Date: 2012-09-07
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Publication No.: US09409978B2Publication Date: 2016-08-09
- Inventor: Stephen J. Doxsey , Tse-Chun Kuo , Chun-Ting Chen
- Applicant: Stephen J. Doxsey , Tse-Chun Kuo , Chun-Ting Chen
- Applicant Address: US MA Boston
- Assignee: University of Massachusetts
- Current Assignee: University of Massachusetts
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2012/054282 WO 20120907
- International Announcement: WO2013/036850 WO 20130314
- Main IPC: C12N15/86
- IPC: C12N15/86 ; A61K38/00 ; C07K16/18 ; C07K14/47
Abstract:
The number of midbody derivatives in a cell may be modulated by modulating autophagy induced by NBR1. Exemplary methods include modulating the amount or activity of NBR1 in the cell, potentiating or inhibiting binding between NBR1 and Cep55 in the cell, or modulating the amount of Cep55 in the cell. These methods can be used in the treatment of cancers or in methods of reprogramming cells.
Public/Granted literature
- US20140314836A1 Modulation of Midbody Derivatives Public/Granted day:2014-10-23
Information query
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