Invention Grant
US09409990B2 Methods of inhibiting tumor growth by antagonizing IL-6 receptor
有权
通过拮抗IL-6受体抑制肿瘤生长的方法
- Patent Title: Methods of inhibiting tumor growth by antagonizing IL-6 receptor
- Patent Title (中): 通过拮抗IL-6受体抑制肿瘤生长的方法
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Application No.: US14329565Application Date: 2014-07-11
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Publication No.: US09409990B2Publication Date: 2016-08-09
- Inventor: Li Zhang
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agent Frank Cottingham; Anna D. DiGabriele-Petti; Karl Bozicevic
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; C07K16/22 ; C07K19/00 ; C07K16/32 ; A61K39/00
Abstract:
The present invention provides methods for inhibiting or attenuating tumor growth in a subject by administering an IL-6 antagonist to the subject. In certain embodiments, the methods of the invention are used to inhibit the growth of an anti-VEGF-resistant tumor in a subject. The IL-6 antagonist may be, e.g., an antibody that specifically binds IL-6R. The IL-6 antagonist may be administered in combination with a VEGF antagonist, and/or an EGFR antagonist.
Public/Granted literature
- US20140322215A1 METHODS OF INHIBITING TUMOR GROWTH BY ANTAGONIZING IL-6 RECEPTOR Public/Granted day:2014-10-30
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