Invention Grant
- Patent Title: Method and compounds for generation of iPSCs
- Patent Title (中): 用于产生iPSCs的方法和化合物
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Application No.: US13402664Application Date: 2012-02-22
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Publication No.: US09410128B2Publication Date: 2016-08-09
- Inventor: Tariq M. Rana
- Applicant: Tariq M. Rana
- Applicant Address: US CA La Jolla
- Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: DLA Piper LLP (US)
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/06 ; C12N5/08 ; C07H21/04 ; C12N5/074 ; G01N33/50 ; C07H21/02
Abstract:
The present invention is based on the seminal concept of combining genomics and chemical biology to identify new agents useful for induced pluripotent stem cell (iPSC) generation. The invention provides a method of generating an iPSC utilizing agents that antagonize a cell specific gene or upregulate expression or activity of a nuclear reprogramming gene, as well as a method of screening for such agents.
Public/Granted literature
- US20120213746A1 METHOD AND COMPOUNDS FOR GENERATION OF iPSCs Public/Granted day:2012-08-23
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