Invention Grant
US09410142B2 Dendrimer-based excipients for the attenuation of protein aggregation
有权
用于减少蛋白质聚集的基于树枝状聚合物的赋形剂
- Patent Title: Dendrimer-based excipients for the attenuation of protein aggregation
- Patent Title (中): 用于减少蛋白质聚集的基于树枝状聚合物的赋形剂
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Application No.: US13884420Application Date: 2011-11-11
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Publication No.: US09410142B2Publication Date: 2016-08-09
- Inventor: Bernhardt L. Trout, II , Diwakar Shukla , Curtiss P. Schneider
- Applicant: Bernhardt L. Trout, II , Diwakar Shukla , Curtiss P. Schneider
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Foley Hoag LLP
- Agent Dana M. Gordon
- International Application: PCT/US2011/060400 WO 20111111
- International Announcement: WO2012/065082 WO 20120518
- Main IPC: C12N9/96
- IPC: C12N9/96 ; C07C279/12
Abstract:
One aspect of the invention is a salt comprising guanidinium groups, as shown in formula I. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula II. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula III. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula IV. Yet another aspect of the invention is a salt comprising guanidinium groups, as shown in formula I, II, III, and IV further comprising independently for each occurrence citrate, phosphate, or sulfate anion. Also disclosed are compositions comprising a protein and a salt comprising guanidinium groups, as shown in formula I, II, III, and IV. Also provided are methods of increasing shelf life of an aqueous solution of a protein and decreasing the amount of protein aggregation in an aqueous solution of a protein.
Public/Granted literature
- US20140004592A1 Dendrimer-Based Excipients for the Attenuation of Protein Aggregation Public/Granted day:2014-01-02
Information query
