Invention Grant
US09410157B2 Systems and methods for the secretion of recombinant proteins in gram negative bacteria
有权
重组蛋白在革兰氏阴性细菌中分泌的系统和方法
- Patent Title: Systems and methods for the secretion of recombinant proteins in gram negative bacteria
- Patent Title (中): 重组蛋白在革兰氏阴性细菌中分泌的系统和方法
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Application No.: US13192058Application Date: 2011-07-27
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Publication No.: US09410157B2Publication Date: 2016-08-09
- Inventor: Sydnor T. Withers, III , Miguel A. Dominguez , Matthew P. DeLisa , Charles H. Haitjema
- Applicant: Sydnor T. Withers, III , Miguel A. Dominguez , Matthew P. DeLisa , Charles H. Haitjema
- Applicant Address: US WI Madison US NY Ithaca
- Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION,CORNELL UNIVERSITY
- Current Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION,CORNELL UNIVERSITY
- Current Assignee Address: US WI Madison US NY Ithaca
- Agency: Casimir Jones S.C.
- Main IPC: C12N15/70
- IPC: C12N15/70 ; C12P21/02
Abstract:
Disclosed herein are systems and methods for producing recombinant proteins utilizing mutant E. coli strains containing expression vectors carrying nucleic acids encoding the proteins, and secretory signal sequences to direct the secretion of the proteins to the culture medium. Host cells transformed with the expression vectors are also provided.
Public/Granted literature
- US20120225453A1 SYSTEMS AND METHODS FOR THE SECRETION OF RECOMBINANT PROTEINS IN GRAM NEGATIVE BACTERIA Public/Granted day:2012-09-06
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