Embodiments of the present invention provide a method and a system for supporting resource isolation in a multi-core architecture. In the method and system for supporting resource isolation in a multi-core architecture provided by the embodiments of the present invention, manners of inter-core operating system isolation, memory segment isolation, and I/O resource isolation are adopted, so that operating systems that run on different processing cores of the multi-core processor can run independently without affecting each other. Therefore, the present invention fully uses the advantages high integration level and low comprehensive costs of the multi-core processor, it is achieved that a failure domain of the multi-core processor remains in a single hard disk, and the multi-core processor has high reliability.