Systems and methods are disclosed for replicating data stored in an in-memory data cache to a remote site. An example system includes an in-memory data cache and an in-memory keys cache. The system also includes a key insert module that detects a modification to the in-memory data cache, identifies one or more keys of the plurality of keys based on the modification, and inserts the identified one or more keys into the in-memory keys cache. The system further includes an update module that retrieves from the in-memory keys cache a set of keys, retrieves from the in-memory data cache modified data associated with the set of keys, and transmits to a remote site a modification list including the set of keys and the modified data associated with the set of keys.