Circuits and methods for detecting, identifying and/or removing undesired content are provided. According to one embodiment, a virus processing system includes a virus co-processor, a first memory, a general purpose processor (GPP) and a second memory. The first memory is communicably coupled to the co-processor via a first memory interface. The first memory includes a first signature compiled for execution on the co-processor. The GPP is communicably coupled to the co-processor. The second memory is communicably coupled to the co-processor via a second memory interface and to the GPP. The second memory includes a second signature compiled for execution on the GPP. The co-processor is operable to retrieve the first signature stored within the first memory through an instruction cache. The co-processor is operable to retrieve a data segment to be scanned from second memory through a data cache that is separate from the instruction cache.