Apparatus and methods calibrate one or more gain ranges for errors. A system can identify offset error and amplification error that occurs when the system transitions from amplifying an input signal by a first gain factor to amplifying the input signal by a second gain factor. To identify the amplification error, the system can compare the slope of the data signal in a source or reference gain range with the slope of the data signal in the destination gain range. To identify the offset error, the system can compare the amplitude of the data signal in a destination gain range with an expected value in the destination gain range.