A transmit and receive RF multiplexer, which includes a first hybrid RF transmit coupler, a first hybrid RF receive coupler, a hybrid RF antenna coupler, and RF bandpass filter and inversion circuitry, is disclosed. The first hybrid RF transmit coupler has a first main transmit port and a pair of transmit ports having a first in-phase transmit port and a first quadrature-phase transmit port. The first hybrid RF receive coupler has a first main receive port and a pair of receive ports having a first in-phase receive port and a first quadrature-phase receive port. The hybrid RF antenna coupler has a main coupler port and a pair of coupler ports having an in-phase coupler port and a quadrature-phase coupler port, such that the main coupler port is coupled to a primary RF antenna.