A method and device for transmitting an uplink signal in a wireless communication system is provided. A user equipment transmits a physical uplink shared channel (PUSCH) on a SRS subframe for a first serving cell to a base station if a SRS transmission on the SRS subframe for the first serving cell is overlapped with an uplink transmission for a second serving cell. The PUSCH is transmitted on remaining orthogonal frequency division multiplexing (OFDM) symbols in the SRS subframe except a single OFDM symbol reserved for the SRS transmission regardless of whether a SRS is transmitted on the single OFDM symbol or not.