Invention Grant
- Patent Title: Dynamic measurement of density using terahertz radiation with real-time thickness measurement for process control
- Patent Title (中): 使用太赫兹辐射进行动态测量,实时测量过程控制
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Application No.: US14273252Application Date: 2014-05-08
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Publication No.: US09417181B2Publication Date: 2016-08-16
- Inventor: Edward King , David Heaps , Mark Sullivan
- Applicant: Advantest Corporation
- Applicant Address: JP Tokyo
- Assignee: ADVANTEST CORPORATION
- Current Assignee: ADVANTEST CORPORATION
- Current Assignee Address: JP Tokyo
- Main IPC: G01N21/3563
- IPC: G01N21/3563 ; G01N21/3581 ; G01N21/3586 ; G01B11/06 ; G01N21/85 ; G01N21/89 ; G01N21/95 ; G01N9/24

Abstract:
A method of determining a density of a roller compacted ribbon is disclosed. The method comprises compacting dry pharmaceutical powder between press rollers of a roller compactor to produce a compact ribbon. The method also comprises determining a thickness at a point on the compact ribbon in a non-invasive manner after it has rolled out from in between the press rollers. Further, the method comprises passing the compact ribbon through a gap in between the terahertz emitter and the terahertz detector. Next, the method comprises determining a refractive index at the point on the compact ribbon using a measurement value from the terahertz emitter and the terahertz detector and a measured value for the thickness at the point. Finally, the method comprises computing a density of the compact ribbon at the point using a value of the refractive index.
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