Invention Grant
- Patent Title: Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
- Patent Title (中): 修饰的核苷，核苷酸和核酸及其用途
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Application No.: US13644072Application Date: 2012-10-03
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Publication No.: US09428535B2Publication Date: 2016-08-30
- Inventor: Antonin de Fougerolles , Atanu Roy , Jason P. Schrum , Suhaib Siddiqi , Paul Hatala , Stephane Bancel
- Applicant: modeRNA Therapeutics
- Applicant Address: US MA Cambridge
- Assignee: Moderna Therapeutics, Inc.
- Current Assignee: Moderna Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/02 ; C12N15/67 ; A61K48/00
Abstract:
The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one or more chemical modifications and a Protein:Cytokine ratio of greater than 100.
Public/Granted literature
- US20130115272A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF Public/Granted day:2013-05-09
Information query
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