Methods, apparatus, and other embodiments associated with objectively predicting disease aggressiveness using Spatially Aware Cell Cluster (SpACCl) graphs. One example apparatus includes a set of logics that acquires an image of a region of tissue, partitions the image into a stromal compartment and an epithelial compartment, identifies cluster nodes within the compartments, constructs a spatially aware stromal sub-graph and a spatially aware epithelial sub-graph based on the cluster nodes and a probabilistic decaying function of the distance between cluster nodes, extracts local features from the sub-graphs, and predicts the aggressiveness of a disease in the region of tissue based on the sub-graphs and the extracted features. Example methods and apparatus may employ a Support Vector Machine classifier to classify super-pixels within the image as stromal super-pixels or epithelial super-pixels.