A method of operating data security and an electronic device supporting the same are provided. The method includes executing a general Application (App) based on a non-trusted execution module; executing a first trusted App related to the execution of the general App based on a trusted execution module; generating a message by encrypting data generated in the first trusted App; transmitting the encrypted message to the general App; and transmitting the encrypted message to a second trusted App related to the execution of the general App and executed based on the trusted execution module.