A prosthetic apparatus configured for implantation in the native mitral valve region of the heart includes a main body that is self-expandable from a compressed state to a radially expanded state. The prosthetic apparatus comprises at least one ventricular anchor coupled to the main body and disposed outside of the main body for capturing a native valve leaflet between the anchor and an outer surface of the main body. In one preferred method of implantation, the prosthetic apparatus is rotated within the native mitral valve region such that a portion of the anchor moves horizontally behind adjacent chordae for anchoring the prosthetic apparatus in the native mitral valve.