- Patent Title: Silicon dioxide nanoparticles and the use thereof for vaccination
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Application No.: US14611891Application Date: 2015-02-02
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Publication No.: US09433673B2Publication Date: 2016-09-06
- Inventor: Markus Weigandt , Andrea Hanefeld , Armin Kuebelbeck , Gregor Larbig
- Applicant: Merck Patent GmbH
- Applicant Address: DE Darmstadt
- Assignee: MERCK PATENT GMBH
- Current Assignee: MERCK PATENT GMBH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano, Branigan, P.C.
- Priority: DE102008033175 20080715
- Main IPC: A61K39/39
- IPC: A61K39/39 ; A61K9/00 ; A61K9/51 ; A61K47/48 ; B82Y5/00 ; A61K39/00
Abstract:
The invention relates to ultrasmall, monodisperse nanoparticles comprising silicon dioxide to the surface of which at least one antigen is attached. The nanoparticles can be used for the immunoprophylaxis or immunotherapy of cancer. The invention also relates to a method for the targeting of antigens at antigen-presenting cells and for the activation of the immune system, where the efficiency of targeting and/or immunoactivation are set via the particle characteristics. The invention also relates to a method for the active and passive immunization of a mammal.
Public/Granted literature
- US20150224189A1 SILICON DIOXIDE NANOPARTICLES AND THE USE THEREOF FOR VACCINATION Public/Granted day:2015-08-13
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