Invention Grant
- Patent Title: Processes for the preparation of isoindole compounds and isotopologues thereof
- Patent Title (中): 异吲哚化合物及其同位素的制备方法
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Application No.: US14642511Application Date: 2015-03-09
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Publication No.: US09434689B2Publication Date: 2016-09-06
- Inventor: Terrence J. Connolly , Alexander L. Ruchelman , Kelvin H. Y. Yong , Chengmin Zhang
- Applicant: Celgene Corporation
- Applicant Address: US NJ Summit
- Assignee: Celgene Corporation
- Current Assignee: Celgene Corporation
- Current Assignee Address: US NJ Summit
- Agency: Jones Day
- Main IPC: C07C315/04
- IPC: C07C315/04 ; C07D209/49 ; C07D209/48 ; C07D209/46
Abstract:
Processes for the preparation of certain isoindole compounds, and isotopologues thereof, are provided. In some embodiments, the processes comprise catalytic asymmetrical hydrogenation with hydrogen gas or deuterium gas in a solvent containing exchangeable proton or deuterium for proton-deuterium exchange.
Public/Granted literature
- US20150183739A1 PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF Public/Granted day:2015-07-02
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