Invention Grant
- Patent Title: Method for preparing linezolid intermediate
- Patent Title (中): 制备利奈唑胺中间体的方法
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Application No.: US14378825Application Date: 2013-02-08
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Publication No.: US09434702B2Publication Date: 2016-09-06
- Inventor: Fuli Zhang , Chunbo Yang , Bin Liang , Pengcheng Qiu , Hairong Luo , Jiang Li , Jian Chai , Qingfeng Cai
- Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd. , Shanghai Institute of Pharmaceutical Industry
- Applicant Address: CN CN
- Assignee: Zhejiang Hisun Pharamceutical Co., Ltd.,Shanghai Institute of Pharmaceutical Industry
- Current Assignee: Zhejiang Hisun Pharamceutical Co., Ltd.,Shanghai Institute of Pharmaceutical Industry
- Current Assignee Address: CN CN
- Agency: Lerner, David, Littenberg, Krumholz & Mentlik, LLP
- Priority: CN201210038198.3 20120215
- International Application: PCT/CN2013/071576 WO 20130208
- International Announcement: WO2013/120448 WO 20130822
- Main IPC: C07D413/06
- IPC: C07D413/06 ; C07D263/20
Abstract:
Disclosed is a new method for preparing a methyl substitute of a linezolid intermediate, (S)-2-(3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazoline) (I), wherein the intermediate (I) is obtained by the cyclization of 3-fluoro-4-morpholinophenyl isocyanate (II) and epoxy compound (III). This process has a short process route, low cost, easy operation, and high yield, so is suitable for a large-scale industrial production.
Public/Granted literature
- US20150011757A1 METHOD FOR PREPARING LINEZOLID INTERMEDIATE Public/Granted day:2015-01-08
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