Invention Grant
- Patent Title: Use of an adrenal hormone-modifying agent
- Patent Title (中): 使用肾上腺激素调节剂
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Application No.: US14079018Application Date: 2013-11-13
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Publication No.: US09434754B2Publication Date: 2016-09-06
- Inventor: Qi-Ying Hu , Gary Michael Ksander , Erik Meredith , Lauren G Monovich , Julien Papillon , Christoph Schumacher
- Applicant: Qi-Ying Hu , Gary Michael Ksander , Erik Meredith , Lauren G Monovich , Julien Papillon , Christoph Schumacher
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Michelle Han
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07F9/6506 ; A61K31/4188 ; A61K31/55

Abstract:
The present invention relates to a method of treating a disease or disorder characterized by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I):wherein n is 1 or 3; R is hydrogen or —C(O)N(Ra)(Rb) wherein Ra and Rb are independently —(C1-C4) alkyl, or —(C1-C4) alkyl-(C5-C7) aryl, wherein each of Ra and Rb is optionally substituted by —(C1-C4) alkoxy; R1, R2, and R3, are independently hydrogen, halogen, cyano or —(C6-C10) aryl, wherein said —(C6-C10) aryl is optionally substituted by halogen, with the proviso that no more than one of R1, R2, and R3 is hydrogen; and R4 and R5 are hydrogen; or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20140171392A1 Use of an Adrenal Hormone-Modifying Agent Public/Granted day:2014-06-19
Information query