Invention Grant
- Patent Title: Macrocyclic cysteine protease inhibitors and compositions thereof
- Patent Title (中): 大环半胱氨酸蛋白酶抑制剂及其组合物
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Application No.: US14206051Application Date: 2014-03-12
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Publication No.: US09434762B2Publication Date: 2016-09-06
- Inventor: Andrew David Abell , James Morriss Coxon , Matthew Alan Jones , Stephen Brian McNabb , Axel Thomas Neffe , Steven Geoffrey Aitken , Blair Gibb Stuart , Janna Marie Nikkel , Joanna Kimberley Duncan , Mutita Klanchantra , James David Morton , Roy Bickerstaffe , Lucinda Jane Goodricke Robertson , Hannah Yun Young Lee , Matthew Stewart Muir
- Applicant: Lincoln University , Canterprise Limited , Douglas Pharmaceuticals Limited
- Applicant Address: NZ Christchurch NZ Lincoln, Canterbury NZ Henderson, Auckland
- Assignee: UNIVERSITY OF CANTERBURY,LINCOLN UNIVERSITY,DOUGLAS PHARMACEUTICALS LIMITED
- Current Assignee: UNIVERSITY OF CANTERBURY,LINCOLN UNIVERSITY,DOUGLAS PHARMACEUTICALS LIMITED
- Current Assignee Address: NZ Christchurch NZ Lincoln, Canterbury NZ Henderson, Auckland
- Agency: Dann, Dorfman, Herrell and Skillman, P.C.
- Priority: NZ550631 20061018
- Main IPC: C07K5/083
- IPC: C07K5/083 ; C07K14/81
Abstract:
The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and compositions are useful in methods of treating or preventing one or more diseases associated with cysteine protease activity, particularly those associated with calpain activity.
Public/Granted literature
- US20140194362A1 Macrocyclic Cysteine Protease Inhibitors and Compositions Thereof Public/Granted day:2014-07-10
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