Invention Grant
- Patent Title: Shigella-derived vector and methods of using the same
- Patent Title (中): 志贺氏菌来源的载体及其使用方法
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Application No.: US14346408Application Date: 2012-09-13
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Publication No.: US09434772B2Publication Date: 2016-09-06
- Inventor: Anthony T. Maurelli
- Applicant: Anthony T. Maurelli
- Applicant Address: US MD Bethesda
- Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Current Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Current Assignee Address: US MD Bethesda
- Agency: MH2 Technology Law Group, LLP
- International Application: PCT/US2012/055097 WO 20120913
- International Announcement: WO2013/043459 WO 20130328
- Main IPC: A61K39/02
- IPC: A61K39/02 ; C12N1/20 ; C12N15/00 ; A61K39/00 ; A61K39/38 ; C07K14/25 ; A61K39/112 ; C12N15/70 ; C12N15/74 ; A61K38/00 ; C12N15/86
Abstract:
Recombinant vectors comprising the cell entry region of the Shigella ox EIEC invasion plasmid are provided, as well as, Shigella or EIEC strains comprising the recombinant vectors. The vectors provide an improved platform for developing attenuated vaccine strains of Shigella or EiEC and for delivering other foreign proteins of interest. The recombinant vectors and bacterial strains comprising the same may be used in methods of inducing an immune response.
Public/Granted literature
- US20140220072A1 SHIGELLA-DERIVED VECTOR AND METHODS OF USING THE SAME Public/Granted day:2014-08-07
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