Invention Grant
US09434778B2 Modified FGF-21 polypeptides comprising an internal deletion and uses thereof
有权
包含内部缺失的修饰的FGF-21多肽及其用途
- Patent Title: Modified FGF-21 polypeptides comprising an internal deletion and uses thereof
- Patent Title (中): 包含内部缺失的修饰的FGF-21多肽及其用途
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Application No.: US14921796Application Date: 2015-10-23
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Publication No.: US09434778B2Publication Date: 2016-09-06
- Inventor: Paul E. Morin , Daniel Cohen , Ranjan Mukherjee , Timothy P. Reilly , Rose C. Christian , Dasa Lipovsek , Ray Camphausen , John Krupinski
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: LeClairRyan, a professional corporation
- Agent Robin L. Teskin
- Main IPC: A61K38/18
- IPC: A61K38/18 ; A61K39/395 ; C07K14/50 ; A61K45/06 ; A61K47/48 ; A61K38/00
Abstract:
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.
Public/Granted literature
- US20160115213A1 Modified FGF-21 Polypeptides and Uses Thereof Public/Granted day:2016-04-28
Information query
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