Invention Grant
US09434822B2 Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
有权
嵌段共聚物,胶束制剂和含有与活性成分相同的抗癌剂
- Patent Title: Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
- Patent Title (中): 嵌段共聚物,胶束制剂和含有与活性成分相同的抗癌剂
-
Application No.: US13971036Application Date: 2013-08-20
-
Publication No.: US09434822B2Publication Date: 2016-09-06
- Inventor: Kazuhisa Shimizu , Keizou Ishikawa , Takeshi Nakanishi
- Applicant: Nippon Kayaku Kabushiki Kaisha
- Applicant Address: JP Tokyo
- Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Nields, Lemack & Frame, LLC
- Priority: JP2004-275625 20040922
- Main IPC: A61K47/34
- IPC: A61K47/34 ; A61K31/337 ; C08G81/00 ; A61K9/107

Abstract:
A medicinal preparation is desired which has no harmful side effects such as hypersensitive reaction, heightens the water solubility of a sparingly water-soluble anticancer agent, maintains a high drug concentration in the blood, accumulates a drug in a tumor tissue at a high concentration, heightens the pharmacological effect of the sparingly water-soluble anticancer agent, and diminishes the side effects of the anticancer agent. Provided are: a novel block copolymer which can be a drug carrier having no harmful side effects such as hypersensitive reaction; a micelle preparation in which micelles are formed and which contains a sparingly water-soluble anticancer agent, especially paclitaxel, incorporated in the micelles in an amount necessary for a disease treatment without bonding it to the block copolymer and which can heighten the solubility of the drug in water; and an anticancer agent which comprises the micelle preparation as a medical ingredient, maintains a high concentration in the blood, has more potent drug activity, and is reduced in toxicity.
Public/Granted literature
Information query
IPC分类: