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US09434935B2 Modified caspase polypeptides and uses thereof 有权
修饰的半胱天冬酶多肽及其用途

Modified caspase polypeptides and uses thereof
Abstract:
The technology relates in part to compositions comprising modified Caspase-9 polypeptides, compositions comprising nucleic acids coding for modified Caspase-9 polypeptides, chimeric modified Caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified Caspase-9 protein, with reduced basal activity in the absence of the inducer.
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