Invention Grant
- Patent Title: Modified caspase polypeptides and uses thereof
- Patent Title (中): 修饰的半胱天冬酶多肽及其用途
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Application No.: US13792135Application Date: 2013-03-10
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Publication No.: US09434935B2Publication Date: 2016-09-06
- Inventor: David Spencer , Wei-Chun Chang
- Applicant: BELLICUM PHARMACEUTICALS, INC.
- Applicant Address: US TX Houston
- Assignee: BELLICUM PHARMACEUTICALS, INC.
- Current Assignee: BELLICUM PHARMACEUTICALS, INC.
- Current Assignee Address: US TX Houston
- Agency: Grant IP, Inc.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/00 ; C12N15/63 ; C12N9/64 ; A61K31/4545 ; A01K67/00

Abstract:
The technology relates in part to compositions comprising modified Caspase-9 polypeptides, compositions comprising nucleic acids coding for modified Caspase-9 polypeptides, chimeric modified Caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified Caspase-9 protein, with reduced basal activity in the absence of the inducer.
Public/Granted literature
- US20140255360A1 MODIFIED CASPASE POLYPEPTIDES AND USES THEREOF Public/Granted day:2014-09-11
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