Invention Grant
US09434992B2 Diagnosis marker, diagnosis method and therapeutic agent for amyotrophic lateral sclerosis, and animal model and cell model developing amyotrophic lateral sclerosis
有权
肌萎缩性侧索硬化症的诊断标志物，诊断方法和治疗剂，以及发展肌萎缩性侧索硬化的动物模型和细胞模型
- Patent Title: Diagnosis marker, diagnosis method and therapeutic agent for amyotrophic lateral sclerosis, and animal model and cell model developing amyotrophic lateral sclerosis
- Patent Title (中): 肌萎缩性侧索硬化症的诊断标志物，诊断方法和治疗剂，以及发展肌萎缩性侧索硬化的动物模型和细胞模型
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Application No.: US14195480Application Date: 2014-03-03
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Publication No.: US09434992B2Publication Date: 2016-09-06
- Inventor: Hideshi Kawakami , Hirofumi Maruyama , Hiroyuki Morino
- Applicant: HIROSHIMA UNIVERSITY
- Applicant Address: JP Hiroshima
- Assignee: HIROSHIMA UNIVERSITY
- Current Assignee: HIROSHIMA UNIVERSITY
- Current Assignee Address: JP Hiroshima
- Agency: Perkins Coie LLP
- Agent Viola T. King
- Priority: JP2009-194864 20090825; JP2010-058294 20100315
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/04 ; A61K31/00 ; C07K14/47
Abstract:
Provided are a diagnosis marker, a diagnosis method, and a therapeutic agent suitable for diagnosing and treating amyotrophic lateral sclerosis (ALS). Also provided are an animal model and a cell model suitable for developing a therapeutic agent and a treatment method for ALS. The diagnosis method for ALS includes: an isolation step in which a nucleic acid is isolated from a specimen taken from a subject; a detection step in which bases expressed in a human chromosome 10 optineurin (OPTN) gene region are detected from the isolated nucleic acid; and a determination step in which it is determined whether or not the detected bases are mutated.
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