An exhaust gas turbocharger module and internal combustion engine outfitted therewith are disclosed. The exhaust gas turbocharger modules have an individual turbocharging assembly with a low-pressure exhaust gas turbocharger with a low-pressure turbine and a low-pressure compressor which have a common first turbocharger axis. A high-pressure exhaust gas turbocharger is provided with a high-pressure turbine and a high-pressure compressor which have a common second turbocharger axis extending perpendicular to the first turbocharger axis. The low-pressure turbine is connected downstream of the high-pressure turbine via an exhaust gas connection line, and the high-pressure compressor is connected downstream of the low-pressure compressor via a charge air connection line. A housing receives the low-pressure turbine, the high-pressure turbine and the exhaust gas connection line. The low-pressure compressor, the high-pressure compressor, and the charge air connection line are arranged outside of the housing.