Invention Grant
US09435812B2 Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration
有权
ETS相关基因（ERG）和磷酸酶和张力蛋白同源物（PTEN）的表达与前列腺癌囊膜浸润相关
- Patent Title: Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration
- Patent Title (中): ETS相关基因（ERG）和磷酸酶和张力蛋白同源物（PTEN）的表达与前列腺癌囊膜浸润相关
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Application No.: US13596266Application Date: 2012-08-28
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Publication No.: US09435812B2Publication Date: 2016-09-06
- Inventor: Gary Pestano , Ray B. Nagle , Connie Cortez , Kristie A. Vanpatten , Amit M. Algotar
- Applicant: Gary Pestano , Ray B. Nagle , Connie Cortez , Kristie A. Vanpatten , Amit M. Algotar
- Applicant Address: US AZ Tucson US AZ Tucson
- Assignee: Ventana Medical Systems, Inc.,The Arizona Board of Regents on behalf of the University of Arizona
- Current Assignee: Ventana Medical Systems, Inc.,The Arizona Board of Regents on behalf of the University of Arizona
- Current Assignee Address: US AZ Tucson US AZ Tucson
- Agency: Klarquist Sparkman, LLP
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/68 ; C12Q1/68
Abstract:
The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be correlated with prostate cancer capsular penetration and more aggressive forms of prostate cancer. Such methods are useful for the prognosis of prostate cancer capsular penetration and for making treatment decisions in patients with prostate cancer that has penetrated the capsule. Also provided are kits that can be used with such methods.
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