Embodiments of the present invention provide a method, system and computer program product for controlling expiration of electronic mail (e-mail) single store attachments. A method to control expiration of e-mail single store attachments can include sending an e-mail message, the e-mail message including one or more attachments, creating a single store linked e-mail message by removing the one or more attachments from the sent e-mail message and replacing each of the one or more attachments with a corresponding single store attachment link. The method further can include storing the removed one or more attachments in an attachment server, where each of the one or more attachments has an expiration date, sending the single store linked e-mail message having the one or more store attachment links to one or more recipients and deleting an attachment stored on the attachment server based upon its respective expiration date having expired. When there is e-mail activity (e.g., forward, reply, etc.) associated with the single store linked e-mail, the expiration of the attachment associated with the attachment link can be modified.