The present disclosure is directed towards a system and method for providing a SPDY to HTTP gateway via a device intermediary to a plurality of clients and a server. An NPN handshake by the intermediary device may establish SPDY support. The intermediary device may receive and process one or more control frames via SPDY session with the client. The intermediary device may generate and transmit HTTP communication to server corresponding to SPDY control frames. The intermediary device may receive and process one or more HTTP responses from server. The intermediary device may generate and transmit SPDY communication via SPDY session to client corresponding to HTTP response.