Multiframe reconstruction combines a set of acquired images into a reconstructed image. Here, which images to acquire are selected based at least in part on the content of previously acquired images. In one approach, a set of at least three images of an object are acquired at different acquisition settings. For at least one of the images in the set, the acquisition setting for the image is determined based at least in part on the content of previously acquired images. Multiframe image reconstruction is applied to the set of acquired images to synthesize a reconstructed image of the object.