Invention Grant
US09439438B2 Methods and compositions for reducing Shiga toxin induced toxicity in mammals
有权
减少志贺毒素诱导的哺乳动物毒性的方法和组合物
- Patent Title: Methods and compositions for reducing Shiga toxin induced toxicity in mammals
- Patent Title (中): 减少志贺毒素诱导的哺乳动物毒性的方法和组合物
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Application No.: US14111444Application Date: 2012-01-18
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Publication No.: US09439438B2Publication Date: 2016-09-13
- Inventor: Adam D. Linstedt , Somshuvra Mukhopadhyay
- Applicant: Adam D. Linstedt , Somshuvra Mukhopadhyay
- Applicant Address: US PA Pittsburgh
- Assignee: Carnegie Mellon University
- Current Assignee: Carnegie Mellon University
- Current Assignee Address: US PA Pittsburgh
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2012/021706 WO 20120118
- International Announcement: WO2012/141773 WO 20121018
- Main IPC: A61K33/32
- IPC: A61K33/32 ; A61K31/28 ; A61K31/4375 ; A61K31/451 ; A61K31/496 ; A61K31/502 ; A61K31/5383 ; A61K45/06 ; A01N59/16
Abstract:
Manganese compositions effective in reducing Shiga toxin-induced toxicity in mammals infected with Shiga toxin-producing bacteria such as E. coli O157:H7 are described. Manganese compositions described herein can be combined with antibiotic therapy as manganese can block the toxic effects of Shiga toxin released from dying bacteria.
Public/Granted literature
- US20140127324A1 METHODS AND COMPOSITIONS FOR REDUCING SHIGA TOXIN INDUCED TOXICITY IN MAMMALS Public/Granted day:2014-05-08
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