Invention Grant
- Patent Title: Androgen receptor down-regulating agents and uses thereof
- Patent Title (中): 雄激素受体下调剂及其用途
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Application No.: US14794416Application Date: 2015-07-08
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Publication No.: US09439912B2Publication Date: 2016-09-13
- Inventor: Vincent C. O. Njar , Lalji K. Gediya , Puranik Purushottamachar , Abhijit Godbole , Andrew Kwegyir-Afful , Tadas Vasaitis
- Applicant: UNIVERSITY OF MARYLAND EASTERN SHORE , THOMAS JEFFERSON UNIVERSITY , UNIVERSITY OF MARYLAND
- Applicant Address: US MD Baltimore
- Assignee: University of Maryland, Baltimore
- Current Assignee: University of Maryland, Baltimore
- Current Assignee Address: US MD Baltimore
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Michael A. Shinall
- Main IPC: A61K31/58
- IPC: A61K31/58 ; A61K45/06 ; A61N5/10 ; C07J43/00
Abstract:
The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds are potential agents for the treatment of all forms of prostate cancer and other diseases that depend on functional AR.
Public/Granted literature
- US20160000808A1 ANDROGEN RECEPTOR DOWN-REGULATING AGENTS AND USES THEREOF Public/Granted day:2016-01-07
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