Invention Grant
US09439922B2 Tat DNA sequences, gene constructs, vaccine and processes thereof
有权
Tat DNA序列，基因构建体，疫苗及其过程
- Patent Title: Tat DNA sequences, gene constructs, vaccine and processes thereof
- Patent Title (中): Tat DNA序列，基因构建体，疫苗及其过程
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Application No.: US12988341Application Date: 2009-05-14
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Publication No.: US09439922B2Publication Date: 2016-09-13
- Inventor: Udaykumar Ranga
- Applicant: Udaykumar Ranga
- Applicant Address: IN Bangalore
- Assignee: JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH
- Current Assignee: JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH
- Current Assignee Address: IN Bangalore
- Agency: Norton Rose Fulbright US LLP
- Agent James R. Crawford
- Priority: IN01174/CHE/2008 20080514
- International Application: PCT/IN2009/000284 WO 20090514
- International Announcement: WO2009/139004 WO 20091119
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07K14/435 ; C12Q1/68 ; C07H21/00 ; C07K14/47 ; A61K31/7088 ; A61K39/21 ; C07K14/005 ; A61K39/12 ; A61K39/00
Abstract:
The present invention relates to non toxic, immunogenic viral Tat DNA sequences comprising wherein the Tat Sequence is rendered non toxic and immunogenic by insertion of T-Helper Epitope into the Cysteine-rich domain, or Basic domain or Core domain of said Tat DNA sequence, optionally along with insertion of a synthetic Intron between C-terminal region and Exon II region of the Tat DNA Sequence. The present invention also relates to elongation factor promoter constructs and process thereof. Also the present invention relates to a process of obtaining the non toxic and immunogenic Tat DNA sequence and vaccine and a method thereof.
Public/Granted literature
- US20110165191A1 TAT DNA SEQUENCES, GENE CONSTRUCTS, VACCINE AND PROCESSES THEREOF Public/Granted day:2011-07-07
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