Invention Grant
US09439970B2 Solid dispersions of insoluble drug and preparation method thereof
有权
不溶性药物的固体分散体及其制备方法
- Patent Title: Solid dispersions of insoluble drug and preparation method thereof
- Patent Title (中): 不溶性药物的固体分散体及其制备方法
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Application No.: US14441277Application Date: 2013-11-07
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Publication No.: US09439970B2Publication Date: 2016-09-13
- Inventor: Myoung Ki Baek , Augustin Pegan
- Applicant: SK BIOPHARMACEUTICALS CO., LTD.
- Applicant Address: KR Seoul
- Assignee: SK BIOPHARMACEUTICALS CO., LTD.
- Current Assignee: SK BIOPHARMACEUTICALS CO., LTD.
- Current Assignee Address: KR Seoul
- Agency: Harness, Dickey & Pierce, P.L.C.
- Priority: KR10-2012-0125516 20121107
- International Application: PCT/KR2013/010088 WO 20131107
- International Announcement: WO2014/073889 WO 20140515
- Main IPC: A61K47/32
- IPC: A61K47/32 ; A61K31/42 ; C07D261/08 ; A61K9/14 ; A61K9/10 ; A61K9/20
Abstract:
The present invention relates to a solid dispersion characterized in that it comprises carbamic acid 3-(4-benzyloxy-phenyl)-isoxazol-5-ylmethyl ester as an active ingredient and a water-soluble polymer having a glass transition temperature lower than the melting point of the active ingredient as a carrier, and it is prepared via melt extrusion. The solid dispersion of the present invention remarkably increases the solubility and dissolution rate of the active ingredient which is an insoluble drug to efficiently improve the bioavailability when it is orally administered.
Public/Granted literature
- US20150283243A1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF Public/Granted day:2015-10-08
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