Invention Grant
- Patent Title: Method for increasing the intraocular pressure in an animal
- Patent Title (中): 增加动物眼内压的方法
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Application No.: US14235097Application Date: 2012-07-27
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Publication No.: US09439981B2Publication Date: 2016-09-13
- Inventor: William Rostene , Christophe Baudouin , David Godefroy , Alexandre Denoyer
- Applicant: William Rostene , Christophe Baudouin , David Godefroy , Alexandre Denoyer
- Applicant Address: FR Paris FR Paris FR Versailles
- Assignee: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE VERSAILLES SAINT-QUENTIN-EN-YVELINES
- Current Assignee: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE VERSAILLES SAINT-QUENTIN-EN-YVELINES
- Current Assignee Address: FR Paris FR Paris FR Versailles
- Agency: Whitham, Curtis & Cook, P.C.
- Priority: EP11305993 20110729
- International Application: PCT/EP2012/064840 WO 20120727
- International Announcement: WO2013/017551 WO 20130207
- Main IPC: A61K31/14
- IPC: A61K31/14 ; A61K49/00 ; A01K67/027
Abstract:
The present invention concerns a method for inducing an increase in the intraocular pressure in an animal, said method comprising ocular administration of a solution comprising benzalkonium chloride (BAK). The present invention further relates to an animal having ocular hypertension, said animal being obtained by the method according to the invention. Said animal provides a convenient animal model for better understanding of the patho-physiological mechanisms involved in ocular hypertension and glaucoma. The present invention also relates to the use of said animal for screening a compound for therapeutic use against ocular hypertension or glaucoma, and/or for assessing potential side-effects of treatment of ocular hypertension and glaucoma.
Public/Granted literature
- US20140178308A1 METHOD FOR INCREASING THE INTRAOCULAR PRESSURE IN AN ANIMAL Public/Granted day:2014-06-26
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