An exemplary system includes 1) a stimulation management facility configured to direct an electro-acoustic stimulation (“EAS”) system to concurrently apply acoustic stimulation to a patient by way of a loudspeaker and electrical stimulation to the patient by way of an electrode located within a cochlea of the patient during a fitting session, and 2) a fitting facility communicatively coupled to the stimulation management facility and configured to detect, during the fitting session, an interaction between the acoustic stimulation and the electrical stimulation, and set, during the fitting session, one or more control parameters governing an operation of the EAS system based on the detected interaction. Corresponding systems and methods are also disclosed.