Invention Grant
- Patent Title: Crystalline ingenol mebutate
- Patent Title (中): 结晶西葫芦mebutate
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Application No.: US14182274Application Date: 2014-02-17
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Publication No.: US09440906B2Publication Date: 2016-09-13
- Inventor: Steven Martin Ogbourne
- Applicant: LEO Laboratories Limited
- Applicant Address: IE Dublin
- Assignee: LEO Laboratories Limited
- Current Assignee: LEO Laboratories Limited
- Current Assignee Address: IE Dublin
- Agency: Fish & Richardson P.C.
- Main IPC: C07C67/52
- IPC: C07C67/52 ; C07C69/533 ; A61K9/00 ; A61K9/06
Abstract:
The present invention relates to a novel crystalline form of ingenol mebutate, methods of preparation thereof, and to its use. More specifically, the invention relates to the conversion of amorphous ingenol mebutate (ingenol-3-angelate, PEP005) to a crystalline form, which was characterized by single crystal X-Ray crystallography (XRC), attenuated total reflectance Fourier transform infrared (FTIR-ATR) spectroscopy and Differential Scanning calorimetry (DSC).
Public/Granted literature
- US20150025265A1 CRYSTALLINE INGENOL MEBUTATE Public/Granted day:2015-01-22
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