Invention Grant
- Patent Title: Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
- Patent Title (中): 用于治疗炎症性疾病的化合物及其药物组合物
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Application No.: US14599644Application Date: 2015-01-19
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Publication No.: US09440929B2Publication Date: 2016-09-13
- Inventor: Christel Jeanne Marie Menet , Oscar Mammoliti , Javier Blanc , Mislav Orsulic , Maja Roscic
- Applicant: GALAPAGOS NV
- Applicant Address: BE Mechelen
- Assignee: GALAPAGOS NV
- Current Assignee: GALAPAGOS NV
- Current Assignee Address: BE Mechelen
- Agency: Klauber & Jackson LLC
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D401/12 ; C07D235/08 ; C07D401/14 ; C07D405/12 ; A61K31/4184 ; A61K31/4439 ; A61K31/5377 ; A61K45/06 ; C07D413/14

Abstract:
The present invention discloses compounds according to Formula I: wherein Cy, R1, L1, R3, R4, R5, La, and Ra are as defined herein. Novel benzimidazoles according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or hypersecretion of interferons.
Public/Granted literature
- US20150203455A1 NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS Public/Granted day:2015-07-23
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