Invention Grant
- Patent Title: Antifibrinolytic compounds
- Patent Title (中): 抗纤维蛋白溶解化合物
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Application No.: US14415474Application Date: 2013-07-17
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Publication No.: US09440989B2Publication Date: 2016-09-13
- Inventor: Josune Orbe Lopategui , Julen Oyarzabal Santamarina , José Antonio Páramo Fernández , José Antonio Rodriguez Garcia
- Applicant: PROYECTO DE BIOMEDICINA CIMA, S.L.
- Applicant Address: ES Zizur Mayor (Navarra)
- Assignee: PROYECTO DE BIOMEDICINA CIMA, S.L.
- Current Assignee: PROYECTO DE BIOMEDICINA CIMA, S.L.
- Current Assignee Address: ES Zizur Mayor (Navarra)
- Agency: Squire Patton Boggs (US) LLP
- Priority: EP12382285 20120718
- International Application: PCT/EP2013/065071 WO 20130717
- International Announcement: WO2014/012964 WO 20140123
- Main IPC: C07D491/107
- IPC: C07D491/107 ; C07D401/12 ; C07D401/04 ; C07D221/20 ; C07C317/48 ; C07D401/06 ; C07D265/34 ; C07D211/34 ; C07C317/14 ; C07D409/06 ; C07D471/10 ; C07D471/20

Abstract:
It relates to spirocyclic compounds of formula (I), or pharmaceutically or veterinary acceptable salts thereof, or any stereoisomers either of the compounds of formula (I) or of their pharmaceutically or veterinary acceptable salts, wherein A and B form a spirocyclic ring system wherein the spiro atom connecting A and B is a carbon atom and wherein A is a known 3- to 8-membered carbocyclic or heterocyclic monocyclic ring or a known 6- to 18-membered carbocyclic or heterocyclic polycyclic ring system; B is a known 4- to 7-membered carbocyclic or heterocyclic monocyclic ring; C is phenyl or a known 5- to 6-membered heteroaromatic ring; and R1-R7 are as defined herein. It also relates to a process for their preparation, as well as to the intermediates used in this process; to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular as antifibrinolytic and antihemorragic agents.
Public/Granted literature
- US20150175618A1 NEW ANTIFIBRINOLYTIC COMPOUNDS Public/Granted day:2015-06-25
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