Invention Grant
- Patent Title: Influenza hemagglutinin protein-based vaccines
- Patent Title (中): 流感血凝素蛋白基疫苗
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Application No.: US14346849Application Date: 2012-09-24
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Publication No.: US09441019B2Publication Date: 2016-09-13
- Inventor: Gary J. Nabel , Masaro Kanekiyo , Chih-Jen Wei , Patrick M. McTamney , Hadi M. Yassine , Jeffrey C. Boyington
- Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Sheridan Ross P.C.
- International Application: PCT/US2012/056822 WO 20120924
- International Announcement: WO2013/044203 WO 20130328
- Main IPC: C07K14/205
- IPC: C07K14/205 ; A61K39/12 ; A61K39/145 ; A61K39/00 ; G01N33/569 ; C07K14/005 ; A61K39/02

Abstract:
Novel vaccines are provided that elicit broadly neutralizing anti-influenza antibodies. Some vaccines comprise nanoparticles that display hemagglutinin trimers from influenza virus on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of ferritin joined to at least a portion of an influenza hemagglutinin protein. Some portions comprise the ectodomain while some portions are limited to the stem region. The fusion proteins self-assemble to form the hemagglutinin-displaying nanoparticles. Some vaccines comprise only the stem region of an influenza hemagglutinin protein joined to a trimerization domain. Such vaccines can be used to vaccinate an individual against infection by heterologous influenza viruses and influenza virus that are antigenically divergent from the virus from which the nanoparticle hemagglutinin protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.
Public/Granted literature
- US20140302079A1 NOVEL INFLUENZA HEMAGGLUTININ PROTEIN-BASED VACCINES Public/Granted day:2014-10-09
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