Invention Grant
- Patent Title: Analytical method for detecting sulfated oligosaccharides
- Patent Title (中): 检测硫酸化低聚糖的分析方法
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Application No.: US13939461Application Date: 2013-07-11
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Publication No.: US09441053B2Publication Date: 2016-09-13
- Inventor: ChungYao Wang , Imin Huang , ChiaYen Wu , YungTe Chiang , Helen Chao
- Applicant: Scinopharm Taiwan, LTD.
- Applicant Address: TW Shan-Hua
- Assignee: ScinoPharm Taiwan, Ltd.
- Current Assignee: ScinoPharm Taiwan, Ltd.
- Current Assignee Address: TW Shan-Hua
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Main IPC: G01N30/02
- IPC: G01N30/02 ; C08B37/00 ; G01N30/88

Abstract:
The present invention describes an analytical method for detecting and quantitating poly-sulfated oligosaccharides, including Fondaparinux sodium, using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC) coupled with a charged aerosol detector (CAD) or a mass spectrometer (MS). This analytical method provides in-process control in a total synthesis of highly sulfated oligosaccharides by separation, quantification and mass identification. Systems and conditions utilizing such methods are also provided.
Public/Granted literature
- US20150013438A1 ANALYTICAL METHOD FOR DETECTING SULFATED OLIGOSACCHARIDES Public/Granted day:2015-01-15
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