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US09441053B2 Analytical method for detecting sulfated oligosaccharides 有权
检测硫酸化低聚糖的分析方法

Analytical method for detecting sulfated oligosaccharides
Abstract:
The present invention describes an analytical method for detecting and quantitating poly-sulfated oligosaccharides, including Fondaparinux sodium, using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC) coupled with a charged aerosol detector (CAD) or a mass spectrometer (MS). This analytical method provides in-process control in a total synthesis of highly sulfated oligosaccharides by separation, quantification and mass identification. Systems and conditions utilizing such methods are also provided.
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