Invention Grant
- Patent Title: Compositions of active Wnt protein
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Application No.: US14824930Application Date: 2015-08-12
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Publication No.: US09441198B2Publication Date: 2016-09-13
- Inventor: Roeland Nusse , Karl H. Willert
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Bozicevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- Main IPC: C07K14/47
- IPC: C07K14/47 ; C07K14/575 ; A61K38/16 ; A61K38/17 ; C12N5/074 ; C12N5/0789
Abstract:
Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein.
Public/Granted literature
- US20150344846A1 Compositions of Active WNT Protein Public/Granted day:2015-12-03
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